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The submission deadline was March 9, 2026. This page is kept for reference purposes.
Measurement of Micronucleus Incidence
AI Summary
Procurement Summary: Measurement of Micronucleus Incidence
Issued By:
Health Canada (HC)
200 Eglantine Driveway, Tunney’s Pasture, Ottawa, Ontario, Canada
Contact Details:
Sami Nouh
Email: [email protected]
Phone: 613-324-8061
Important Dates:
- Posted: February 11, 2026
- Proposal Due: March 9, 2026, by 2:00 PM EST
- Contract Performance Period: From contract award until March 31, 2026, with two (2) optional one-year extensions.
Project Title: Measurement of Micronucleus Incidence in Urothelial and Buccal Epithelial Cells Collected from Wildland Firefighters
Scope and Objectives:
The project aims to measure the incidence of micronucleus (MN) in urinary urothelial cells and buccal epithelial cells from wildland firefighters involved in active fire suppression. These measurements are intended to serve as early biomarkers for cancer risk associated with firefighting, following the 2024 Prevention and Treatment of Cancers Linked to Firefighting Act. The objective includes conducting an initial pilot study with 12 local samples to refine the protocol, followed by the collection of 90 samples per fiscal year.
Key Deliverables:
- Collection and analysis of cell samples for MN incidence determination.
- Delivery of data that helps address knowledge gaps regarding firefighter cancer risks and potential mitigation strategies.
Mandatory Requirements:
- Offerors must comply with Canada's Code of Conduct for Procurement.
- Legal capacity to contract and provide applicable certifications.
- Ability to handle biosamples and implement specific methodologies for sample preparation and MN analysis.
Preferred Qualifications:
- Experience in genotoxicity testing and related biomarker analysis.
- Familiarity with laboratory protocols for handling biological samples from human subjects.
- Knowledge of the health risks associated with firefighting activities and relevant public health frameworks.
Evaluation Criteria:
Proposals will be evaluated based on completeness, adherence to submission requirements, and demonstrated qualifications, specifically emphasizing experience in similar projects. Factors such as technical competency in relevant methodologies, ability to deliver the required scientific analysis, timeliness and precision of data collection, and compliance with health and safety regulations will also impact evaluation.
Geographic Restrictions:
No specific geographic restrictions mentioned for the offerors; however, the samples will be collected from Canadian wildland firefighters within the jurisdiction of the project.
This procurement provides a significant opportunity for specialized firms experienced in genomic health assessments, particularly in occupational health sectors related to firefighting.
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Documents
Description
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Contract Period: From contract award until March 31, 2026 with two (2) one year option periods. 1. TITLE Measurement of Micronucleus Incidence in Urothelial and Buccal Epithelial Cells Collected from Wildland Firefighters 2. SCOPE 2.1. Introduction Firefighters have an increased risk of chronic cardiovascular diseases, respiratory diseases, and cancer. In 2024, the Government of Canada passed the Prevention and Treatment of Cancers Linked to Firefighting Act; one of the objectives is the establishment of a national framework whereby awareness about cancers linked to firefighter is increased. Early biomarkers of genotoxic effects, such as micronucleus (MN) incidence in targeted cell populations, can be used to monitor cancer risk (Fenech et al., 2020). More specifically, the presence of MN in bladder urothelial cells has been empirically and mechanistically linked to cancer (Arora et al., 2010; Espinoza et al., 2019). Similarly, MN in buccal (oral) epithelial cells have also been linked to an increased risk of cancer (Bolognesi et al., 2015). Health Canada (HC) is seeking a contractor to measure the incidence of MN in urothelial cells and buccal epithelial cells collected from wildland firefighters. The work is part of the deliverables outlined in an HC project entitled Genotoxic Effects as Early Biomarkers of Cancer Risk in Wildland Firefighters. The project is funded under the aforementioned national framework on cancers linked to firefighting. 2.2. Objectives of the Requirement The objective of the requirement is to measure the incidence of MN in urothelial cell samples and buccal epithelial cell samples collected from wildland firefighters engaged in active fire suppression. HC will first perform a small study that will utilize urine samples and mouth swab samples collected from 12 local individuals; these will serve as pilot samples to evaluate an in-house protocol for the preparation of samples derived from urine and buccal swabs. Subsequently, HC will collect 90 samples per fiscal year (FY) from wildland firefighters engaged in active fire suppression. Urothelial cells and buccal epithelial cells will be isolated from urine and buccal swabs, respectively, fixed, placed on glass microscope slides, and suitably stained for MN incidence determination. The MN incidence data will allow HC researchers Page 42 of 48 to address knowledge gaps pertaining to firefighter cancer risk; moreover, mitigation strategies to reduce risk.
Additional Information
Source
canadabuys
Status
closed
Procurement Method
Competitive - Open bidding
Procurement Category
Services
Selection Criteria
Highest Combined Rating of Technical Merit and Price
Regions of Opportunity
Canada
Regions of Delivery
Ottawa *National Capital Region (NCR)
Reference Number
cb-588-61505140
Amendment Number
001
Contracting Entity
Department of Health (HC)
Contact Name
Sami Nouh
Contact Email
Contact Phone
+16133248061
Contact Country
Canada
Organization City
Ottawa
Organization Province / State
Ontario
Organization Country
Canada
Last Updated
March 10, 2026
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The proposal submission deadline is March 9, 2026 (Overdue).
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