This opportunity has closed
The submission deadline was March 9, 2026. This page is kept for reference purposes.
Measurement of Micronucleus Incidence
AI Summary
Summary of Opportunity: Measurement of Micronucleus Incidence
Issuing Organization:
Department of Health (Health Canada)
Ottawa, Ontario, Canada
Contact: Sami Nouh
Email: [email protected]
Phone: 613-324-8061
Project Title: Measurement of Micronucleus Incidence in Urothelial and Buccal Epithelial Cells Collected from Wildland Firefighters
Contract Type: Contract, with a performance period from contract award until March 31, 2026, and two (2) one-year option periods.
Important Dates:
- Posted: February 11, 2026
- Due Date for Proposals: March 9, 2026, by 2:00 PM EST
Project Scope and Objectives:
Health Canada is procuring a contractor to measure the incidence of micronuclei (MN) in urothelial and buccal epithelial cells from wildland firefighters. This initiative is part of a national framework aimed at increasing awareness regarding cancers linked to firefighting as mandated by the Prevention and Treatment of Cancers Linked to Firefighting Act. The project will involve an initial small pilot study to validate sample preparation protocols, followed by the collection of 90 samples per fiscal year from active firefighters. The deliverables include preparation and analysis of urine and mouth swab samples, isolation of targeted cells, and determination of MN incidence to inform on cancer risk and potential mitigation strategies.
Key Technical Capabilities Needed:
- Expertise in genotoxicity testing
- Sample processing and analysis of urothelial and buccal epithelial cells
- Proficiency in microscopy and staining techniques for MN determination
Mandatory Qualifications:
- Proven experience in handling biological samples and conducting genotoxicity studies
- Compliance with Canada's Code of Conduct for Procurement
- Legal capacity to contract with Health Canada
Preferred Qualifications (Competitive Advantage):
- Previous experience with firefighter health studies
- Knowledge of cancer risk factors associated with firefighting
- Established protocols for the analysis of MN in biological samples
Deliverables and Performance Standards:
- Conduct a pilot study followed by sample testing based on specified methodologies
- Provide comprehensive reports with MN incidence data
- Meet deadlines for submission of samples and analysis results
Evaluation Criteria:
- Completeness and accuracy of proposals
- Relevant experience and technical capabilities
- Pricing and overall cost-effectiveness
- Ability to comply with timelines and deliverables
Set-Aside Requirements:
There are no specific set-aside requirements mentioned in the opportunity details.
Geographic Restrictions:
No specific geographic restrictions noted; however, the contractor must operate within Ottawa, Ontario, Canada, for compliance and reporting purposes.
This summary is intended to match companies with the relevant expertise and experience to effectively respond to this significant health study opportunity related to firefighter cancer risks.
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Description
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Contract Period: From contract award until March 31, 2026 with two (2) one year option periods. 1. TITLE Measurement of Micronucleus Incidence in Urothelial and Buccal Epithelial Cells Collected from Wildland Firefighters 2. SCOPE 2.1. Introduction Firefighters have an increased risk of chronic cardiovascular diseases, respiratory diseases, and cancer. In 2024, the Government of Canada passed the Prevention and Treatment of Cancers Linked to Firefighting Act; one of the objectives is the establishment of a national framework whereby awareness about cancers linked to firefighter is increased. Early biomarkers of genotoxic effects, such as micronucleus (MN) incidence in targeted cell populations, can be used to monitor cancer risk (Fenech et al., 2020). More specifically, the presence of MN in bladder urothelial cells has been empirically and mechanistically linked to cancer (Arora et al., 2010; Espinoza et al., 2019). Similarly, MN in buccal (oral) epithelial cells have also been linked to an increased risk of cancer (Bolognesi et al., 2015). Health Canada (HC) is seeking a contractor to measure the incidence of MN in urothelial cells and buccal epithelial cells collected from wildland firefighters. The work is part of the deliverables outlined in an HC project entitled Genotoxic Effects as Early Biomarkers of Cancer Risk in Wildland Firefighters. The project is funded under the aforementioned national framework on cancers linked to firefighting. 2.2. Objectives of the Requirement The objective of the requirement is to measure the incidence of MN in urothelial cell samples and buccal epithelial cell samples collected from wildland firefighters engaged in active fire suppression. HC will first perform a small study that will utilize urine samples and mouth swab samples collected from 12 local individuals; these will serve as pilot samples to evaluate an in-house protocol for the preparation of samples derived from urine and buccal swabs. Subsequently, HC will collect 90 samples per fiscal year (FY) from wildland firefighters engaged in active fire suppression. Urothelial cells and buccal epithelial cells will be isolated from urine and buccal swabs, respectively, fixed, placed on glass microscope slides, and suitably stained for MN incidence determination. The MN incidence data will allow HC researchers Page 42 of 48 to address knowledge gaps pertaining to firefighter cancer risk; moreover, mitigation strategies to reduce risk.
Additional Information
Source
canadabuys
Status
closed
Procurement Method
Competitive - Open bidding
Procurement Category
Services
Selection Criteria
Highest Combined Rating of Technical Merit and Price
Regions of Opportunity
Canada
Regions of Delivery
Ottawa *National Capital Region (NCR)
Reference Number
cb-588-61505140
Amendment Number
000
Contracting Entity
Department of Health (HC)
Contact Name
Sami Nouh
Contact Email
Contact Phone
+16133248061
Contact Country
Canada
Organization City
Ottawa
Organization Province / State
Ontario
Organization Country
Canada
Last Updated
March 9, 2026
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